Ruggeri M, Pagan E, Bagnardi V, et al. - Researchers conducted the HOHO European protocol, a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns and here they sought to report on the baseline data and focus on predictors of fertility concerns. Using patient surveys and medical record review, they identified 297 eligible respondents. Of these, 67% discussed issues regarding fertility before starting therapy, 64% were concerned about becoming infertile after treatment, and 15% chose not to follow prescribed therapies. Before diagnosis, wish for future children was reported in 54% of women; of these, 71% still desired biologic children afterwards. In multivariable analysis, the only patient characteristic that was significantly associated with fertility concerns at diagnosis was not having children. Fertility preservation strategies were used in 27%. Women who received chemotherapy, vs those who did not, reported greater physical and sexual difficulties. Psychosocial problems were less evident among women who were married or had a partner than single women. Several concerns were reported in young women with newly diagnosed breast cancer, including, but not limited to, fertility.