You Y, Fan Q, Huang J, et al. - Studies suggest that ferroptosis, a new type of iron-dependent cell death characterized by the formation of lipid peroxides and excessive accumulation of reactive oxygen species, modifies tumor genesis, progression, and invasion, including ovarian cancer. Using the mRNA expression data from TCGA, researchers herein developed a scoring system by applying consensus clustering analysis, univariate Cox regression analysis, and least absolute selection operator. Thereafter, the relationship between score and clinical characteristics of ovarian cancer was evaluated. As per result from the prediction of biofunction pathways, score is suggested to be an independent prognostic marker for ovarian cancer and that it affects tumor progression by modulating tumor metastasis. In addition, the tumor microenvironment in a high-score group had greater infiltration of immunocytes such as activated CD4 T cell, activated CD8 T cell, regulatory T cells, macrophage, and stromal cells, including adipocytes, epithelial cells, and fibroblast, suggesting that ferroptosis can also influence tumor immune landscape. Based on the scores, they critically predicted four potentially sensitive drugs, including staurosporine, epothilone B, DMOG, and HG6-64-1, and recognized DMOG as a novel targeted drug for ovarian cancer. In general, a scoring system was developed on the basis of ferroptosis-related genes that can aid in predicting the prognosis of ovarian cancer patients and a proposal was made that ferroptosis may influence ovarian cancer progression by mediating tumor metastasis and immune landscape.