Female obesity increases the risk of miscarriage of euploid embryos
Fertility and Sterility Dec 12, 2020
Cozzolino M, Velasco JAG, Meseguer M, et al. - A retrospective, observational, multicenter cohort study was designed to ascertain if female body mass index (BMI) is correlated with an elevated risk of miscarriage after euploid embryo transfer. Researchers divided 3,480 cycles of in vitro fertilization with preimplantation genetic testing for aneuploidy in the blastocyst stage and euploid embryo transfer into four groups according to patient BMI. The miscarriage rate, which included both biochemical and clinical miscarriages was the primary outcome. Secondary outcomes included implantation, pregnancy, clinical pregnancy, and live birth rates. This study’s findings revealed that women with obesity experience a higher rate of miscarriage after euploid embryo transfer than women with a normal weight, implying that other mechanisms than aneuploidy are responsible for this outcome.
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