Hornum M, et al. - Given the possible value of calcium channel blockers in ameliorating the decline in renal function caused by calcineurin inhibitors in lung transplant (LTX) recipients, researchers here investigated if the decline in glomerular filtration rate (GFR) in LTX recipients could be reduced with preoperative and 12-week postoperative treatment with the calcium channel blocker, felodipine. They conducted a prospective randomized, double-blind trial including 39 LTX recipients; these were transplanted and were administered placebo (n = 19; GFR, 102 mL/min/1.73 m² [range, 91–113 mL/min/1.73 m²]) or felodipine ( n = 20, GFR 96 mL/min/1.73 m² [range, 88–104 mL/min/1.73 m²]). Outcomes revealed greater preservation in renal function early (90 days) after LTX in select patients in correlation to using felodipine. They recognized attenuation of the observed benefits by 1 year although trends in better renal function were seen.