Kurita Y, Kuwahara T, Hara K, et al. - Since the diagnosis of small pancreatic lesions by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is challenging in patients with chronic pancreatitis (CP), researchers ascertained if CP influences the diagnostic ability of EUS-FNA for pancreatic lesions ≤ 10 mm. For this retrospective study, 117 patients who had EUS-FNA for pancreatic lesions ≤ 10 mm in size were recruited. In accordance with the Rosemont classification, patients were classified into two groups based on features of CP observed by EUS (EUS-CP features). According to results, diagnostic ability of EUS-FNA had sensitivity (80.4%, 96.7% vs 57.1%), specificity (100%, 100% vs 100%), and accuracy (91.5%, 98.6% vs 80.4%). Findings suggested that EUS-FNA provides high precision for small pancreatic lesions ≤ 10 mm. However, EUS-FNA's diagnostic ability is significantly reduced in cases with CP.