Anwar S, Cock C, Young J, et al. - Researchers conducted this retrospective analysis to examine the prevalence of clinically significant serrated polyps in a cohort undergoing their index and their first follow-up colonoscopy and to characterize the demographic and morphological characteristics associated with a finding of high-risk serrated polyps. Polyp pathology at the index and first follow-up colonoscopy performed between 2004 and 2019 in patients enrolled in a surveillance program due to an index finding of adenoma and/or sessile serrated polyp (SSP) were investigated. After 3.3 years, 2,035 of the 6,297 patients who had an index colonoscopy had a follow-up colonoscopy. At the first follow-up colonoscopy, the prevalence of SSP is reduced by one-third, but the proportion of SSP with high-risk features remains unchanged. While females were more likely to have a high-risk SSP at the index colonoscopy, those with a high-risk SSP at the follow-up colonoscopy were age >75 years and had an index high-risk SSP.