Montisci R, et al. – The goal of this research was to characterize the safety profile, utility, adverse events, and rate of complications of the test in women with suspected coronary artery disease. The data indicated that noninvasive assessment of coronary flow velocity reserve in left anterior descending coronary artery by transthoracic echocardiography was considered to be a feasible technique with very low incidence of adverse events and complications in women with suspected or known coronary artery disease. Moreover, it is safe and can be used when evaluating female patients with atherosclerotic left anterior descending coronary artery disease or with coronary microvascular impairment.