Frego N, Saita A, Casale P, et al. - The present study was performed to explore the feasibility, safety, and effectiveness of ultrasound-guided transperineal laser ablation (TPLA) as a new minimally invasive surgical therapy (MIST) for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). Researchers conducted TPLA using a continuous-wave diode laser (SoracteLite-EchoLaserX4) able to generate a light-induced thermal heating and subsequent coagulative necrosis of the prostatic tissue. Individuals were assessed at 3, 6, and 12 months after TPLA. They prospectively enrolled 22 consecutive patients (median age 61.9 years). For BPH, TPLA of the prostate appears to be a promising MIST. Before implementations of this technique in the urologist’s armamentarium, long-term results and comparative studies against standard treatments are warranted.