Sethi SK, et al. - This study assessed the feasibility, and tolerability of sustained low-efficiency dialysis (SLED) in critically sick pediatric patients. Findings demonstrated the feasibility of SLED in this patient population.

Methods

• Researchers performed a retrospective record review from January 2010 to June 2016 in 4 tertiary pediatric nephrology centers in India.
• Study participants included all pediatric patients undergoing SLED in the collaborating centers.
• They recorded basic demographic data, prescription parameters and outcomes of patients.

Results

• Overall, 68 children received 211 sessions of SLED during this study.
• Data reported that PRISM score at admission in patients was 13.33 ± 9.15 and 57 patients were ventilated (84%).
• It was also noted that most of the patients had one or more organ system involved in addition to renal (n = 64; 94%).
• Researchers observed that heparin free sessions were achievable in 153 sessions (72%).
• 148 out of 211 sessions were on at least one inotrope (70.1%).
• Findings demonstrated that premature terminations had to be done in 27 sessions (13% of all sessions), out of which 7 sessions had to be terminated due to circuit clotting (3.3%).
• In addition, it was reported that intradialytic hypotension or need for inotrope escalation was seen in 31 (15%) sessions but termination of the session for drop in BP was required in only 20 (9%) sessions.