Watanabe K, Mori M, Hishiki T, et al. - In western countries, children with high-risk hepatoblastoma showed dramatically improved outcomes in correlation with receiving dose-dense cisplatin-based chemotherapy in the SIOPEL-4 study.

• A pilot study, JPLT3-H, was conducted to evaluate the feasibility and safety of this regimen in Japanese patients.

• Enrolled were a total of 15 patients (median age: 2 years (range, 0–14); three females).

• There were three patients PRETEXT II (where PRETEXT is PRETreatment EXTent of disease), six patients PRETEXT III, and six patients PRETEXT IV.

• Lung metastasis was recorded in all patients, none of these had low alpha-fetoprotein.

• In JPLT3-H, a toxicity profile comparable to that of SIOPEL-4 was evident.

• Overall findings support feasibility of dose-dense cisplatin-based chemotherapy among Japanese patients with high-risk hepatoblastoma.