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Feasibility and reliability of sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer patients with positive axillary nodes at initial diagnosis: An up-to date meta-analysis of 3,578 patients

The Breast Jul 29, 2021

Cao S, Liu X, Cui J, et al. - Via carrying out a meta-analysis, researchers sought to provide a consensus concerning the application of sentinel lymph node biopsy (SLNB) post-Neoadjuvant chemotherapy (NACT) in breast cancer (BC) patients with positive axillary nodes (cN+). Performing a comprehensive database search, 27 studies were retrieved (3,578 patients). Overall findings suggest technical feasibility of performing SLNB following NACT for BC with cN+. For SLNB, the pooled estimate of identification rate (IR) was 91 %, and false negative rate (FNR) was 15 %. Decrease in the FNR could clearly be achieved with the application of dual mapping.

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