Assanto GM, Ciotti G, Brescini M, et al. - A retrospective observational monocentric cohort study was performed to evaluate the favourable prognostic role of high basal maximal standardized uptake value in follicular lymphoma. For this analysis, all individuals affected by follicular Lymphoma (FL) who had undergone basal staging PET/CT were enrolled. Researchers distinguished two subgroups and compared them in terms of PFS and OS: A) Basal SUVmax < 6; B) Basal SUVmax > 6. The study enrolled a total of 94 individuals, 34 in group A (36,2%) and 60 in group B (63,8%). The findings illustrate the independent prognostic role of baseline SUVmax as a PFS predictor, particularly in individuals with low-risk FL. Individuals with low tumor metabolic activity exhibit a higher long-term relapse probability even without other risk factors. The data indicate that baseline SUVmax assessment, with its simple evaluation, could help distinguish individuals at risk for late relapse, requiring strict follow-up and, potentially, MRD monitoring.