Knorr S, et al. - In this prospective nationwide follow-up study, researchers assessed the impact of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the connection between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163; a marker of macrophage activation) and fatty liver risk. The study sample consisted of offspring (n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects (n = 303). Compared to unexposed control subjects, more type 1 diabetes–exposed offspring had a high fatty liver index and waist-to-height ratio indices. Maternal type 1 diabetes intrauterine exposure and higher maternal prepregnancy BMI may predispose offspring to fatty liver. Fatty liver indices are correlated with offspring metabolic risk factors, including sCD163 levels.