Schechter SA, et al. - In the present study, the researchers sought to assess the significance of fat necrosis with an associated lymphocytic infiltrate as a histopathologic clue for distinguishing cellular dermatofibromas (CDFs) from dermatofibrosarcoma protuberans (DFSP). Cases in the pathology database with a primary diagnosis of CDF or DFSP were identified. Punch or excisional biopsy specimens with extension into the subcutis have been selected. Previously biopsied lesions and specimens that did not interact with the subcutis have been excluded. Findings suggested that fat necrosis with associated lymphocytic response may help to distinguish between CDF and DFSP.