Marra NF, et al. - In this retrospective, registry-based, cross-sectional study, researchers evaluated the influence of fasting insulin resistance on the prevalence of metabolically healthy obesity (MHO) in adolescents and identified associated factors. Study participants included 418 (51.9% girls) 10- to 18-year-old adolescents with obesity from a tertiary outpatient clinic in Sao Paulo, Brazil between 2009 and 2013. Investigators estimated MHO prevalence according to two definitions: no cardiometabolic risk factors (CMRF) by the International Diabetes Federation parameters and no CMRF and homeostatic model assessment for insulin resistance <3.16. Findings revealed that the prevalence of metabolically healthy obesity decreased when insulin resistance was part of the definition. The detection of pre-clinical insulin resistance can improve the management of adolescents seeking treatment, particularly if they do not have a CMRF. They observed that male and later pubertal stages were also less likely to have MHO, but neither was significant in definition II.