Han X, et al. - Among 520 obese children (aged 3.4-17.1 years), experts aspired to explore if fasting C-peptide represented a risk factor for nonalcoholic fatty liver disease (NAFLD). According to hepatic ultrasound results, participants were divided into two groups, obese with NAFLD and non-NAFLD. For this investigation, they measured fasting plasma glucose, fasting C-peptide, hemoglobin A1c, renal function, liver function, blood lipid, fasting insulin and blood routine indices. According to results, obese children with NAFLD had higher fasting C-peptide, fasting insulin and HOMA-IR compared with the non-NAFLD group. The results indicated that obese children with a high level of fasting C-peptide had an increased risk of developing NAFLD. According to fasting C-peptide tertiles, the adjusted OR for NAFLD were 1.00, 1.896, and 4.169.