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Family history of cancer and subsequent risk of cancer: A large-scale population-based prospective study in Japan

International Journal of Cancer Oct 18, 2019

Hidaka A, Sawada N, Svensson T, et al. - Researchers undertook a Japanese population-based prospective study with adjustment for lifestyle habits to assess the association of family history (FH) of cancer and concordant cancer risk. The study was initiated in 1990 for cohort I and in 1993 for cohort II. They performed analysis of data on 103,707 eligible individuals without a history of cancer who replied to a self-administered questionnaire including FH of cancer at baseline. During 1,802,581 person-years of follow-up, they identified a total of 16,336 newly diagnosed cancers among these individuals. Observations suggest the association of having FH of cancer with an increased risk of several concordant cancer incidences in an Asian population. This suggests the significance of enquiring about FH of several types of cancer in identifying groups at high-risk of those cancers.
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