Visvanathan K, et al. – Researchers conducted this multicenter study to determine risk/protective factors related to Serous tubal intraepithelial carcinoma (STIC)/Serous tubal intraepithelial lesions (STILs) and to characterize p53 signatures in the fallopian tube. For invasive cancer/STICs/STILs, they reviewed fallopian tubes and ovaries of 479 high-risk women > 30 years of age who had bilateral risk-reducing salpingo-oophorectomy. Using descriptive statistics, they performed comparisons between groups with and without lesions. They found that the protective factors that were related to high-grade serous ovarian carcinoma (HGSC) were possibly not shared by the STICs/STILs. Most likely, these factors were only related to STICs that progressed to HGSC. The disease progression could be predicted by the presence of multiple lesions in the fimbria.