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Failure of concurrent chemoradiotherapy for organ preservation in laryngeal cancer: Survival outcomes and recurrence patterns

ENT Journal Aug 19, 2019

Aydil U, Akmansu M, Gümüşay O, et al. - In the patients who had a recurrence after concurrent chemoradiation (CRT) for laryngeal cancer, researchers determined the failure patterns and the survival results. Clinical records of patients in a tertiary referral center who had definitive concurrent CRT for laryngeal cancer were evaluated between 2001 and 2014. Data reported that the most common recurrence pattern was a local recurrence in 21 patients followed by regional recurrence in 11 patients. This research shows that survival results in CRT failures are unfavorable, and careful selection of patients is critical to minimizing failures. Disease course is very aggressive and systemic treatment is not effective in the presence of systemic recurrence.
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