D'Souza N, Delisle TG, Chen M, et al. - This is the first powered, multicentre, double-blinded diagnostic accuracy study to evaluate whether a faecal immunochemical test (FIT) could be used to select patients with suspected colorectal cancer (CRC) symptoms for urgent investigation. Between October 2017 and December 2019, 9,822 patients were involved in the final analysis. Data reported that the prevalence of CRC at colonoscopy was 3.3%. At the lowest cut-off (2 g/g), FIT sensitivity is maximised to 97.0%; a negative FIT result at this cut-off effectively rules out CRC, and a positive FIT result is better than symptoms in selecting patients for urgent investigations.