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Faecal immunochemical test after negative colonoscopy may reduce the risk of incident colorectal cancer in a population-based screening programme

Gut Jun 10, 2021

Peng SM, Hsu WF, Wang YW, et al. - Researchers conducted the study for comparing the risk of incident colorectal cancer (CRC) in subsets of populations that received and did not receive subsequent faecal immunochemical test (FIT) screening after negative colonoscopy, which refers to a colonoscopy without the finding of any neoplastic lesion, including invasive cancer, advanced or non-advanced adenoma and traditional or sessile serrated adenoma, in the Taiwanese CRC Screening Program. They included 9,179 individuals who had a negative diagnostic colonoscopy after a positive FIT between 2004 and 2009, with 6,195 receiving subsequent FIT during the study period. Findings suggested an association of higher baseline faecal haemoglobin concentration with increased risk of incident CRC. In a national FIT screening programme, the subsequent FIT should be scheduled after a negative colonoscopy to detect missed neoplasms and lower the risk of incident CRC.

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