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Factors predictive of long-term mortality in lupus nephritis: A multicenter retrospective study of a Japanese cohort

Lupus Mar 14, 2019

Ichinose K, et al. - A sum of 120 individuals were evaluated to study the relationship between the complete renal response (CR) and mortality in lupus nephritis (LN) at Nagasaki University Hospital and community hospitals in Nagasaki between the years 1990 and 2016. They recorded the death of 9 cases during the follow-up period due to cardiovascular events, infection, malignancy and other causes. They observed the 5-, 10-, 15- and 20-year survival rates, 99.3, 94.6, 92.0 and 85.4%, respectively. They found the following factors predictive of CR, at 6 months: male gender, proteinuria (g/gCr) and index of activity (0–24) and at 12 months: male gender and index of activity (0–24). They concluded an association of survival rate of patients with LN with the achievement of CR at 12 months after induction therapy. Male gender and a higher index of activity (0–24) were considered as the predictive factors for failure to achieve CR at 6 and 12 months.
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