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Factors in premature infants associated with low risk of developing retinopathy of prematurity

JAMA Ophthalmology Feb 18, 2019

Wade KC, et al. - Researchers undertook a study in North American neonatal intensive care units where clinicians had expertise in retinopathy of prematurity (ROP), to determine the characteristics of infants at low risk for ROP, for whom further postdischarge screening may be of limited value. Between 31 and 47 weeks’ postmenstrual age, 4113 ROP examinations were done in a total of 1257 infants born at 22 to 35 weeks’ gestation (median [interquartile range (IQR)], 26 [25-28] weeks) with birth weights less than 1251 g (median [IQR], 860 [690-1040] g). ROP by discharge was not identified in two-thirds of the infants born at 27 weeks’ gestational age or older with birth weights greater than 750 g and ROP treatment was not required in any of the infants without ROP by 37 weeks’ postmenstrual age. This suggested a limited value of further examinations in infants with no ROP by discharge with larger birth weights and more advanced gestational age.
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