Sánchez-Valverde F, et al. - In this retrospective, observational study, researchers investigated the factors that were related to the development of immune tolerance in children with cow’s milk allergy (CMA). The participants underwent the same clinical follow-up methodology. Overall 245 cases of CMA (125 IgE-mediated and 120 non-IgE-mediated) were examined. Non-IgE-mediated CMA and patients receiving casein hydrolysate with Lactobacillus rhamnosus GG (LGG) were identified as the factors that were related to earlier tolerance. Caesarean delivery and breastfeeding for a period of at least 3 days were related to later tolerance. The recovery time was influenced by the type of formula and the type of CMA, as revealed in the multivariate study. In IgE-mediated and non-IgE-mediated CMA, a reduction in recovery time was evident in relation to casein hydrolysates with LGG.