Hui CLM, et al. - Given that not all patients with psychotic disorders require a lifetime of antipsychotic treatment, researchers reported the proportion and factors associated with successful discontinuation during long-term follow-up of patients with first-episode psychosis. A study of patients in the schizophrenia spectrum found that 24 out of 70 (34%) were free of antipsychotic medication for at least 3 months after an average disease duration of 10.4 years, of which 20 were medication-free for more than one year. Another study of first-episode psychosis reported that that 17 of 103 patients (16.5%) had stopped the antipsychotic medication in the previous two years during the seven-year follow-up. It is of considerable importance to identify clinical characteristics of disease associated with a lower or higher probability of successfully discontinuing the antipsychotic medication.