Guo Z, et al. - Individuals with diabetic foot ulcer (DFU) referred to the Third Xiangya Hospital during the period between December 2014 and September 2018 were recruited in this study in order to examine the potential risk factors prognosticating amputations in these patients. Those who needed amputation manifested significantly greater levels of white blood cell counts, platelet counts, erythrocyte sedimentation rate, CRP, and HbA1c levels. Nevertheless, in cases with amputations, levels of hemoglobin, postprandial plasma C-peptide, triglyceride, HDL-C, albumin, and uric acid were reduced. Much greater rates of amputation were noted in individuals with more advanced Wagner grades. In the stepwise logistic regression model, multivariable-adjusted odds ratios was 1.317, 0.255, and 20.947 for HbA1c, triglyceride, and Wagner grades, respectively. Thus, in these Chinese diabetic foot ulcer individuals, raised HbA1c level, lower triglyceride level, and higher Wagner grades were the independent risk factors for amputation.