Restrepo-Escobar M, et al. - Via a retrospective cohort study of pediatric systemic lupus erythematosus (SLE) patients admitted to two intensive care units (ICUs), the researchers intended to recognize determinants and outcomes associated with infection in pediatric SLE patients at admission and during hospitalization in ICUs. Among 55 patients, 73 infection episodes were assessed. At admission, 29 episodes were recorded and these patients had the CRP higher than the non-infected patients. Further, during hospitalization, 25 episodes happened. An association of lupus activity, cyclophosphamide, and mechanical ventilation with infection was found. Death was observed in 10 episodes accounting to 14% of the total cases. Therefore, high CRP should warn clinicians to a possible infection in pediatric lupus patients admitted to the ICU. Furthermore, SLE activity and cyclophosphamide during hospitalization were related to infection. Also, admission to the ICU because of infection was greatly correlated with mortality.