Meireles MV, et al. - Researchers aimed at determining clinical, sociodemographic, and treatment-related factors associated with early virological response in HIV-infected adults starting antiretroviral treatment (ART) in Brazil in 2014–2015. They created a historical cohort via combining data from 4 information systems from the Brazilian AIDS Program. As per findings, immediate initiation of ART regardless of clinical stage or CD4+ is supported. The multivariate analysis yielded following factors that increase the odds of non-viral load suppression (VLS): lower CD4+ and higher viral load counts, younger age, heterosexual or injection drug use groups (relative to men who have sex with men), lower educational level, black/brown race, higher pill burden, and higher dosing frequency. In this work, Regimens containing boosted protease inhibitors were similar to those containing nonnucleoside reverse transcriptase inhibitors and superior to those containing unboosted protease inhibitors.