Alejandro A, et al. - Given that pediatric invasive fungal rhinosinusitis (PIFR) is a potentially lethal infection seen in immunocompromised pediatric patients, researchers analyzed the factors associated with all-cause mortality in pediatric patients with acute invasive fungal rhinosinusitis. This investigation was carried out at the tertiary pediatric referral center. Participants in the study were 18 patients (12 male and 6 female). Acute lymphoblastic leukemia was the most common cause of immunosuppression. The only factor found to affect mortality was a period of more than seven days between diagnosis and surgery. According to results, PIFR is a high mortality aggressive entity. In order to improve survival, an appropriate diagnosis with an opportune surgical debridement followed by systemic antifungal therapy is necessary. Higher mortality is associated with delays in surgical treatment.