Stolic RV, et al. - Researchers conducted this investigation to determine the factors that might influence the function of arteriovenous fistulas (AVFs). In this study, maintaining fistula patency seemed crucial after successful establishment of an AVF. Results suggested some clinical factors (concentration of the magnesium and antiplatelet therapy) that could determine long term fistula duration.

Methods

• For a 2-year period, researchers collected data from the computerized patient record system in the Clinic of Urology and Nephrology, Clinical Center, Kragujevac, Serbia.
• Patients who had requested re-creation of AVFs as a secondary procedure were analyzed.
• One hundred and twelve patients [73 (65%) men and 39 (35%) women] had AVF thromboses during this period .
• They determined all relevant clinical and laboratory parameters that could affect the function and survival of AVF.

Results

• Univariate logistic regression analysis suggested that magnesium (P < 0.001), triglycerides (P=0.041), smoking (P=0.001), antiplatelet therapy (P < 0.001), and type of HD (bicarbonate vs. hemodiafiltration) (P < 0.001) were statistically significant predictors influencing the duration of the fistula.
• The multiple logistic regression model indicated that the length of AVF function was significantly associated with high concentrations of magnesium (B = 7434; P < 0.001) and antiplatelet therapy (B - 1.042; P=0.04).