EZH2 modulates the DNA methylome and controls T cell adhesion through junctional adhesion molecule-A in lupus patients
Arthritis & Rheumatism Oct 10, 2017
Tsou PS, et al. - The role of EZH2 in CD4+ T cells upon lupus pathogenesis is depicted in this study. They identified a novel role for EZH2 in T cell adhesion mediated by epigenetic remodeling and upregulation of JAM-A. They also noted that blocking EZH2 or JAM-A might have a therapeutic potential in lupus by decreasing T cell adhesion, migration, and extravasation.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty -
Paid Market Research Surveys -
Case discussions, News & Journals' summaries
