Extremes of age decrease survival in adults after lung transplant
Chest Aug 19, 2019
Lehr CJ, et al. - Given the implication of age as a factor in the plateau of long-term survival following lung transplant, researchers explored risk-factors for death in 14,253 recipients of lung transplant aged ≥ 18 years of age identified from the Scientific Registry of Transplant Recipients. They analyzed age as both a continuous and categorical variable (age < 30, 30-55, and > 55 years). At all time-points after transplant, age was identified as the most significant risk factor for death and its influence became more prominent as the time from transplant increased. For all patients, extremes of age, higher creatinine, single lung transplant, hospitalization prior to transplant, and increased bilirubin were reported as risk factors for death. The lowest posttransplant survival was reported in the youngest and oldest adult recipients, via divergent pathways which may offer opportunities for intervention to improve survival post- lung transplant.
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