Patel SH, et al. - For 172 patients with lower-grade gliomas, pre- and postsurgical glioma volumes were defined via a semiautomated segmentation software based on FLAIR or T2-weighted MR imaging sequences by the researchers in order to discover the influence of surgical resection on overall survival in lower-grade glioma molecular subtypes. Postsurgical glioma volume and the percentage of resection were correlated with overall survival, for the entire cohort. The percentage of resection was correlated with overall survival for isocitrate dehydrogenase (IDH)-mutant 1p/19q-codeleted oligodendrogliomas. For IDH-mutant 1p/19q-noncodeleted astrocytomas, presurgical glioma volume, postsurgical glioma volume, and percentage of resection had a correlation with overall survival. Pre-/postsurgical glioma volume and percentage of resection were no link with overall survival, for IDH-wild-type lower-grade gliomas. Hence, in patients with lower-grade gliomas, the extent of surgical resection has a differential survival influence on the basis of their molecular subtype. Moreover, IDH-mutant lower-grade gliomas profited from a huge extent of surgical resection, with the strongest influence seen for IDH-mutant 1p/19q-noncodeleted astrocytomas.