Isanaka S, et al. - This investigation is an extended follow-up of a randomized clinical trial of routine amoxicillin use for infants experiencing uncomplicated severe acute malnutrition (SAM) in Niger. Children (aged 6 to 59 months) who presented with SAM in Madarounfa, Niger were randomly assigned 1:1 to receive amoxicillin (80 mg/kg/d) or a placebo for 7 days between October 2012 and November 2013. For this expanded analysis, all 2,399 children from the primary analysis were eligible for inclusion. Results of this clinical trial with extended follow-up from admission to 12 weeks indicate no longer-term advantage in the treatment of uncomplicated SAM from daily antibiotic use.