Karamagkiolas S, et al. - Researchers estimated tissue specimens of 69 candidates with laryngeal squamous cell carcinoma (LSCC) to study the possible combined prognostic significance of NOTCH1, Vimentin (VIM), and Metastasis-associated 1 (MTA1) protein in LSCC using immunohistochemistry. In Kaplan-Meier survival analysis, they noted no importance of NOTCH1 expression status as a prognosticator in LSCC. But they found an important prognostic potential of both VIM and MTA1, independent of TNM staging as well as the histological grade of the tumor. In fact, in contrast to MTA1, the positive expression of which predicts higher disease-free survival (DFS) and overall survival (OS) rates in LSCC, positive VIM expression has been shown to predict patients' relapse and poor outcome regarding OS of subjects.