Kimura S, D’Andrea D, Iwata T, et al. - Among patients who underwent radical prostatectomy (RP) for prostate cancer (PCa), this inquiry was performed to determine the prognostic role of expression of urokinase-type plasminogen activator system members, such as urokinase-type activator (uPA), uPA-receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1). This analysis included 3,121 patients who were treated with RP. In 1,012 (32.4%), 1,271 (40.7%), and 1,311 (42%) patients, the overexpression of uPA, uPAR, and PAI-1 was identified, respectively. Findings revealed that overexpression of uPA, uPAR, and PAI-1 in PCa tissue were each related to worse biochemical recurrence. Even in cases with favorable pathologic features, overexpression of all three markers was identified to be informative potentially assisting clinical decision-making about adjuvant treatment and/or intensified follow-up.