Amano Y, et al. - Using immunohistochemistry, authors investigated the expression of protein arginine methyltransferases (PRMT) 5 in surgically resected oral epithelial dysplasia (OED), oral intraepithelial neoplasia (OIN)/carcinoma in situ (CIS) and OSCC with or without contiguous OED lesions. Data exhibited a connection between concomitant nuclear and cytoplasmic expression of PRMT5 with the loss of E-cadherin and cytokeratin 17, and the upregulation of vimentin. These features were indicative of epithelial-to-mesenchymal transition. It was found to be probable that PRMT5 played a role from early oncogenesis through to the progression of OSCC, especially in the aggressive mode of stromal invasion.