Tao L, Chen Y, Shi X, et al. - In this retrospective analysis of a large series of nasopharyngeal carcinoma (NPC) tissue samples, researchers analyzed the expression as well as the clinicopathologic significance of somatostatin receptor 2a (SSTR2a) in NPC. This study included 106 primary NPC samples, consisting of 99 primary non-keratinizing NPC (NK-NPC) and 7 keratinizing NPC samples, and 41 metastatic NPC samples. Also, a control group comprising 24 cases of normal nasopharyngeal mucosa tissues was involved. Expression of SSTR2a was identified in most cases of primary NK-NPC. Negative expression of other neuroendocrine markers, such as synaptophysin, chromogranin A, and CD56, was noted in all cases of NPC. These revelations broaden the spectrum of recognized SSTR2a-positive tumors. For the first time, frequent expression of SSTR2a in primary and metastatic NK-NPC was evident in this study, emphasizing that SSTR2a has potential as a scintigraphic as well as treatment target in this disease.