Hussein UK, et al. - In the present study, researchers examined the expression of oxidized-protein tyrosine phosphatase (PTP) and phosphorylated-H2AX (γH2AX) in human gastric carcinoma tissue samples and assessed the usefulness of the expression of oxidized-PTP and γH2AX as prognostic markers of gastric carcinomas. For this investigation, they assessed the clinical significance of the expression of oxidized-PTP and γH2AX in 169 gastric carcinomas. In the progression of gastric carcinomas, oxidative stress-mediated oxidation of PTP might be involved. The findings from the present study suggested that individual and co-expression pattern of nuclear oxidized-PTP and γH2AX might be useful as a prognostic marker of gastric carcinomas patients.