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Expression of chemerin correlates with a poor prognosis in female breast cancer patients

Breast Cancer: Targets and Therapy Oct 31, 2018

El-Sagheer G, et al. - Researchers analyzed chemerin expression in breast cancer tissue vs the adjacent normal tissue and determined how it relates to disease prognosis. They examined the association of chemerin expression with the patients’ clinical and pathological features. In malignant vs adjacent normal breast tissue, a higher chemerin expression was observed. A significant correlation of chemerin expression with weight, body mass index, tumor size, lymph node metastasis, distant metastasis, and tumor grading was noted, while an inverse significant correlation of it with estrogen receptor and progesterone receptor expression was evident in malignant breast tissues. In breast cancer patients, poor prognosis might be independently predicted by chemerin tissue expression. Patients with higher chemerin expression had worse overall survival vs those with a lower chemerin expression, as revealed by the Kaplan–Meier survival curves.

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