Zhang Q, Zong L, Zhang H, et al. - Researchers examined B7 homolog 3 (B7-H3) expression patterns in patients with cervical cancer. In addition, they described its correlations with programmed cell-death ligand 1 (PD-L1), pathological features, and survival. Assessing tissue microarrays from 552 patients with stage IB1 and IIA1 cervical cancer, they identified expression of B7-H3 in the tumor cells (TCs) of 32.1% of the samples as well as in the stromal cells of 92.9% of the specimens. Findings suggest a promising prognostic value of B7-H3 positivity in TCs. Squamous cell carcinoma, PD-L1-positive samples, and tissues from patients with lymph node metastasis more frequently expressed B7-H3 in TCs; in addition, its expression was an independent predictor of shorter survival. Targeting B7-H3 alone or in combination with PD-1/PD-L1 is suggested to be a potential immunotherapeutic strategy for patients with cervical cancer.