Tsiaoussis GI, et al. - The role of innate and adaptive immune system of intestinal mucosal barrier function in cirrhosis was examined in this analysis. For the purpose of this investigation, 40 patients with decompensated, 27 with compensated cirrhosis and 27 controls were subjected to duodenal biopsy. Results of this study suggested that decreased expression of antimicrobial peptides could be considered as a potential pathophysiological mechanism of intestinal barrier dysfunction in liver cirrhosis. On the other hand, remodeling of gut-associated lymphoid tissue as an acquired immune response to bio-pathogens remains an open field to illuminate.