Pelletier JP, et al. - Authors sought to determine the determinants associated with a better response to intra-articular hyaluronic acid (IAHA) treatment in knee osteoarthritis (OA) subjects. High levels of knee pain, younger age, and less severe structural damage were identified as reliable predictive determinants that could distinguish patients who could benefit best from IAHA treatment. In clinical practice, these could be implemented as a useful guide for physicians.