Granzier RWY, et al. - Sixteen studies with cohort sizes varying from 35 to 414 persons were involved in order to systematically review the current literature and reflect on its quality, to evaluate the quality of the radiomics workflow using the Radiomics Quality Score (RQS) and to report on the various methodologies used in all consecutive steps of the radiomics workflow. Methodologies in the radiomics workflow differed greatly, particularly in region of interest segmentation, peculiarities selection, and model development with heterogeneous outcomes as a result. Seven studies applied univariate and nine applied multivariate analysis. Most studies conducted their analysis on the pretreatment dynamic contrast-enhanced T1-weighted sequence. Thus, large methodological heterogeneity for each step of the MRI-based radiomics workflow was shown, hence, the (overall promising) results are complex to be contrasted. Moreover, to further enhance research, in breast cancer individuals, consensus for standardization of MRI-based radiomics workflow for tumor response prognostication to neoadjuvant systemic therapy is required.