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Exploration of the role of anti-Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome

Clinical Endocrinology Mar 20, 2019

Le MT, et al. - In this multicentre cross-sectional descriptive study, which included 863 infertile women (aged 18 to 45 years), researchers investigated the role of anti-Mullerian hormone (AMH) and LH/FSH ratio in the diagnosis of polycystic ovary syndrome (PCOS). With the AUC 0.852, AMH showed sensitivity and specificity of 78.50% and 75.83% respectively at an optimum cut-off level of 32.79 pmol/L. In the diagnosis of PCOS, the value of serum AMH concentration was found not significantly higher than the LH/FSH ratio. Although these biomarkers are not adequate separately for the diagnosis of PCOS based on their own value, the combination of various endocrine factors including AMH, LH and LH / FSH ratio together with BMI and other anthropometric and clinical characteristics may provide extra value for the diagnosis of PCOS.
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