Li H, Ding X, Terkeltaub R, et al. - This research was carried out to assess the impacts of metformin on cartilage and pain in osteoarthritis mouse model. Researchers randomized a total of 80 10-week-old male C57BL/6 mice to 6 groups: non-operation, sham-operation, destabilization of the medial meniscus (DMM)-operation with intragastric saline/metformin, and DMM-operation with intraarticular saline/metformin. They analyzed articular cartilage degeneration by scanning electron microscopy (SEM) and graded using the scoring system recommended by Osteoarthritis Research Society International (OARSI). The results of this study demonstrated that metformin attenuates osteoarthritis structural worsening and modulates pain, implying its potential for osteoarthritis prevention or treatment.