Ma M, et al. - Using resting-state functional magnetic resonance imaging, depression-related abnormalities were ascertained in the intrinsic brain activity of interictal migraineurs with comorbid depression. Findings revealed joint effects of migraine and depression on left medial prefrontal cortex (mPFC), which is thought to be the neural basis of self-referential mental activity and has been shown the increased amplitude of low-frequency fluctuation (ALFF) in depression patients. In thalamus and fusiform, they observed different developmental trajectory suggesting that the comorbidity may arise through a specific mechanism rather than simple superposition of migraine and depression.