Ciccarese F, Piccinino A, Brocchi S, et al. - This study was attempted to present the radiological manifestation of immune-related adverse events (irAES) detectable by CT. Researchers conducted a retrospective analysis including a total of 284 patients who treated with immune checkpoint inhibitors (ICI) for various types of advanced cancer; of them, 129 patients were selected, all having been treated with single-agent ICI, and all with a baseline CT scan and follow-up scans available at our Institute. The data demonstrate that radiologists should be aware of the wide spectrum of irAES as they could affect the outcome. Pneumonia was found to be the most frequent irAES; nevertheless, the international classification for interstitial lung disease does not appear to be capable of describing all possible drug-related pulmonary toxicities. Transient Asymptomatic Pulmonary Opacities, radiation recall pneumonia, and sarcoid-like reaction were the additional findings.