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Exosomal TUBB3 mRNA expression of metastatic castration-resistant prostate cancer patients: Association with patient outcome under abiraterone

Cancer Medicine Aug 02, 2021

Zhu S, Ni Y, Sun G, et al. - The researchers wanted to use ddPCR to quantify plasma exosomal class III β-tubulin (βIII-tubulin, TUBB3, encoded by the TUBB3 gene) mRNA expression in patients with metastatic castration-resistant prostate cancer (mCRPC) and investigate the relationship between this expression and abiraterone efficacy. Blood samples were collected prospectively from 52 mCRPC patients receiving abiraterone as first-line therapy to assess plasma exosomal TUBB3 mRNA expression levels prior to starting abiraterone. The exosomal TUBB3 mRNA expression level is linked to poor PSA-PFS of abiraterone in mCRPC patients. Exosomal TUBB3 detection may be useful in their management.

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