Zhou CS, Feng MT, Chen X, et al. - In patients with lung adenocarcinoma (LUAD), researchers determined the expression as well as prognostic role of exonuclease 1 (EXO1) in this study. Three cohorts were analyzed to assess prognostic value of EXO1 in LUAD cases. In LUAD tissues and paired para-cancer tissues, EXO1 expression levels were analyzed. A high expression of EXO1 was evident in LUAD tissues vs para-cancerous tissues in public databases, which was consistent with the researchers’ data. In LUAD, a poor prognosis in relation to high expression of EXO1 was identified in the survival analysis. In enrichment analyses, biological pathways such as cell cycle regulation, DNA damage and repair, immune response, and neuroactive ligand-receptor interaction, may be related to aberrant expression of EXO1. Based on these data, experts suggest EXO1 as a potential prognostic biomarker in LUAD. A correlation of EXO1 with infiltrating levels of immune cells in the tumor microenvironment was revealed in this study.